A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold.

A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold.

We used a biophysical model of an isolated dendritic spine to assess quantitatively the impact of changes in spine geometry, Ca2+ buffer concentration, and channel kinetics on Ca2+ dynamics following high-frequency activation of N-methyl-D-aspartate receptors. We found that varying the buffer concentration in the postsynaptic density from 50 to 500 microM can result in an 8-fold difference in t...

Mechanism for a sliding synaptic modification threshold

Long-term potentiation (LTP) is a long-lasting increase in synaptic effectiveness that results from high frequency stimulation (HFS) of certain excitatory synapses in hippo-campus and neocortex (reviewed by Bliss and Colling-ridge, 1993). Because it is induced by brief episodes of electrical stimulation that resemble patterns observed in the brains of behaving animals, and because it can be ver...

investigating the feasibility of a proposed model for geometric design of deployable arch structures

deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...

The h current is a candidate mechanism for regulating the sliding modification threshold in a BCM-like synaptic learning rule.

Hebbian synaptic plasticity acts as a positive feedback mechanism and can destabilize a neuronal network unless concomitant homeostatic processes that counterbalance this instability are activated. Within a Bienenstock-Cooper-Munro (BCM)-like plasticity framework, such compensation is achieved through a modification threshold that slides in an activity-dependent fashion. Although the BCM-like p...

In a Bcm-like Synaptic Learning Rule the H Current Is a Candidate Mechanism for Regulating the Sliding Modification Threshold